Download ABC of Clinical Haematology (ABC Series) by Drew Provan PDF

By Drew Provan

This moment version of the ABC of medical Haematology is a complete and sensible advisor to this large ranging speciality, overlaying the haematological elements of such parts as pathology, molecular technology, melanoma, and basic drugs. this can be a brief quantity such as chapters on all components of haematology written by means of those who take care of those ailments each day. The booklet offers descriptions of those illnesses and describes the pathways concerned about analysis and remedy. complete color is used all through this seriously illustrated booklet, utilizing medical fabric and textual content packing containers to stress key issues. we now have additionally attempted to maintain jargon to a minimal in order that the textual content doesn't require huge previous wisdom.

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Extra resources for ABC of Clinical Haematology (ABC Series)

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The Ph chromosome is derived from a normal 22 chromosome that has lost part of its long arm as a result of a balanced reciprocal translocation of chromosomal material involving one of each pair of chromosomes 9 and 22; thus the translocation is t(9;22)(q34;q11). The Ph chromosome (also known as 22q–) therefore appears somewhat shorter than its normal counterpart, and the 9q+ somewhat longer than the normal chromosome 9. The Ph chromosome carries a specific fusion gene known as bcr– abl, which results from juxtaposition of part of the abl proto-oncogene (from chromosome 9) with part of the bcr gene on chromosome 22.

Often the disease is detected as a result of routine blood tests performed for unrelated reasons, and up to 50% of patients are totally asymptomatic at the time of diagnosis. The spleen may be greatly enlarged before the onset of symptoms. Treatment that reduces the leucocyte count to normal usually restores the spleen to normal size. Much rarer features at presentation include non-specific fever, lymphadenopathy, visual disturbances due to leucostasis (a form of hyperviscosity caused by an extremely high white cell count) or retinal haemorrhages, splenic pain due to infarction, gout and occasionally priapism.

G. g. g. tuberculosis) • Autoimmune disease Hepatosplenomegaly • Lymphoproliferative disease • Myeloproliferative disease • Storage disease • Autoimmune disease • Tropical disease Myelodysplasia Lymphoblastic lymphoma Infection Neutropenia (reduced neutrophil count) is common at diagnosis, and results in an increased risk of both bacterial and fungal infection. Bacterial infection in the throat, skin or perianal region is commonly seen and may be missed unless the relevant areas are carefully examined.

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