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By Shaker A. Mousa

1This number of evaluate articles highlights the most recent improvement of antithrombotics and offers confirmed experimental equipment for the additional improvement of recent and superior anticoagulants. one of the state-of-the-art advancements reviewed are the unconventional utilization of low molecular weight heparins, such antithrombin brokers because the hirudin, and such antiplatelet medications because the GPIIb/IIIa inhibitors and ADP receptor antagonists. extra ideas mentioned contain aspirin and clopidogrel, the extended use of polytherapeutic methods, antiproteases (factors IIa, Xa, and VIIa), tissue issue focusing on, platelet receptor focusing on, and antithrombin III modulation.

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Extra resources for Anticoagulants, Antiplatelets, and Thrombolytics (Methods in Molecular Medicine)

Sample text

Current Opinion in Investigational Drugs 2, 1086–1092. 9. Mousa, S. A. (1999) Antiplatelet therapies: recent advances in the development of platelet GPIIb/IIIa antagonists, in Current Interventional Cardiology Reports, Vol. 1. (Holmes, D. ), Current Science, Philadelphia, PA, pp. 243–252. 10. , et al. (1998) Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa inhibitors. Blood 92, 3240–3249. 11. Holmes, M. , Sobel, B. , Cannon, C.

2. Prior to the perfusion experiment, incubate blood with either a platelet antagonist or vehicle (control) at 37°C for 10 min. 3. , 1 min). Platelet-substrate interactions are monitored in real time using an inverted microscope equipped with an epifluorescent illumination attachment and siliconintensified target video camera, and recorded on videotape (see Note 6). The microscope stage and flow chamber are maintained at 37°C by an incubator heating module and incubator enclosure during the experiment.

Circulation 90, 2126–2146. 4. , and McIntire, L. V. (1998) Biomechanics of cell interactions in shear fields. Adv. Drug Delivery Rev. 33, 141–164. CH03,21-34,14pgs 9/5/03 11:01 AM Page 33 In Vitro Flow Models of Thrombosis 33 5. Alevriadou, B. , Moake, J. , Turner, N. , Ruggeri, Z. , Folie, B. , Phillips, M. , et al. (1993) Real-time analysis of shear dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets. Blood 81, 1263–1276. 6. Turitto, V. T.

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