By Thomas Ming Swi Chang
This can be a finished and primary type overview of approximately all vital and primary advancements of artifiical cells via the nestor of this department in utilized biomedial technology himself. This "bible" is vital interpreting for either novices and the skilled expert. Chang wrote a great and stimulating evaluation over 50 years of synthetic phone learn and improvement and purposes.
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Extra resources for Artificial Cells: Biotechnology, Nanomedicine, Regenerative Medicine, Blood Substitutes, Bioencapsulation, Cell/Stem Cell Therapy (Regenerative Medicine, Artificial Cells and Nanomedicine)
One of these has been approved for routine use in South Africa (Lok, 2001). Conjugated Hb (Fig. 1) In 1964, Chang showed that in the presence of both diamine and Hb, sebacyl chloride can crosslink hemolgobin to polymers to form insoluble conjugated Hb (Chang, 1964, 1965) (Fig. 2). This method has been extended to produce (intramolecular) soluble conjugated Hb (Fig. 1) formed by the linking of one Hb molecule to soluble polymers, as prepared by Sunder in 1975; Wong in 1976; Iwashita in 1980; and the Enzon group in 1988.
They are also known as nanoparticles, nanocapsules, polymersomes, nanotubules, etc. , 1965). They used these as a membrane model for basic membrane research. D. in biochemistry at McGill, he came to see me to discuss his future areas of research. I encouraged him to look into different ways of forming artiﬁcial cells for delivery of biologics. His subsequent research in England on the use of liposomes as drug delivery systems opened a whole new approach (Gregoriadis, 1976). , 1965) limits the amount of drugs or biologics that can be enclosed.
1. Introduction As discussed in the last chapter, nanobiotechnology is the assembling of biological molecules into one of the following categories: nanodimension structures, membranes with nanodimension thickness, and nanotubules with nanodimension diameter. The ﬁrst nanobiotechnology approach reported in the literature is the crosslinking of Hb into ultrathin polyhemoglobin (PolyHb) membrane with nanodimension thickness for artiﬁcial cell membrane (Chang, 1964, 1965) (Fig. 2). If the emulsions are made very small, then the whole submicron artiﬁcial cells can be crosslinked into PolyHb of nanodimension.